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The phantom line method is still an acceptable practice as an alternative to using the U modifier symbol. It is straightforward to understand, so if you are working with someone less familiar with GD&T, indicating a unilateral tolerance zone this way may be a better option. However, the preferred method is to use the U modifier as outlined in the 2009 ASME standard.
Two systematic reviews have summarised the efficacy and safety of BH4. Somaraju et al. [458] reviewed 2 randomised controlled trials that were led respectively by Levy et al. [447] and Trefz et al. ([459], whereas Lindegren et al. [448] included the following additional studies/reports: one uncontrolled open-label study, one prospective cohort study, and several case series. Both systematic reviews concluded there is short-term evidence to demonstrate that BH4 is effective in reducing blood Phe concentrations and increasing Phe tolerance in BH4-responsive PKU patients. Also no serious adverse events were reported. Several uncontrolled open-label studies and case series support a significant reduction of blood Phe levels [193, 194, 311, 433, 442, 444,445,446,447,448,449,450,451, 453,454,455, 458,459,460,461,462,463,464] and increased Phe tolerance [193, 194, 311, 433, 443,444,445,446, 448,449,450,451,452, 454, 455, 458, 459, 463,464,465]. These benefits have also been replicated in longer-term (investigated up to 5 years) studies [193, 194, 443, 445, 446, 451, 454, 455, 463, 465]. Furthermore, less variability in blood Phe control has been described in 3 descriptive papers [311, 454, 460]. Current data suggests that with BH4 treatment cognition and behaviour issues may improve but, possibly, more importantly they do not deteriorate [155, 183, 466]. The same applies for quality of life [58, 165]. At present, studies have not reported long-term neurocognitive outcome, behaviour and quality of life with BH4 treatment. 2b1af7f3a8